Furthermore, the long latent period observed by Satou et al. before the onset of T-cell lymphomas in HBZ-Tg mice suggests that additional epigenetic alterations in CD4+ T-cells are necessary for the development of T-cell lymphomas in HBZ-Tg mice as well as for ATL [89]. The gene discussed is CD4; the disease is T-cell non-Hodgkin lymphoma.