Therefore, although we have not yet determined the precise role of ICAM-1 and VCAM-1 expression in CRC cells, ICAM-1 and VCAM-1 in the resistin-treated cancer and endothelial cells may be secreted into the cancer microenvironment and mediate the interactions of cancer, immune, and endothelial cells. This evidence concerns the gene VCAM1 and colorectal carcinoma.