Therefore, although we have not yet determined the precise role of ICAM-1 and VCAM-1 expression in CRC cells, ICAM-1 and VCAM-1 in the resistin-treated cancer and endothelial cells may be secreted into the cancer microenvironment and mediate the interactions of cancer, immune, and endothelial cells. The gene discussed is RETN; the disease is colorectal carcinoma.