In acute ischemic stroke, the re-establishment of cerebral blood flow was caused by the treatment of tissue plasminogen activator (t-PA) within 4.5 h after the symptom onset, and the intravenous administration with recombinant t-PA (rt-PA) within a few hours after the onset of ischemic attack has also been demonstrated by the National Institute of Neurological Disorders and the Stroke rt-PA Stroke Study Group [6]. This evidence concerns the gene PLAT and Stroke.