Overrepresentation of high mannose, hybrid and paucimannosidic type N-glycans and under-representation of complex N-glycans in CRC tissues; higher sialylation, in particular α2,6-sialylation, in CRC tissues, coupled with down-regulation of α2,3-sialylation; high α2,3-sialylation and low bisecting β1,4-GlcNAcylation and Lewis-type fucosylation in mid-late stage CRC tissues, relative to early stage CRC;high bisecting β1,4-GlcNAcylation and low α2,3-sialylation in EGFR-positive tissues. Here, EGFR is linked to colorectal carcinoma.