On the other hand levels of conventional tumor markers (which are used to monitor treatment and detect recurrence in serum of patients with various malignancies) such as cancer antigen 125 (CA125), CA19-9, CA72-4, CA715-3, alpha-fetoprotein (AFP), Neuron-specific Enolase (NSE), cytokeratin-19 fragment (CYFRA 21-1), Epidermal Growth Factor Receptor (EGFR) and beta- human chorionic gonadotropin (β-hCG) β-human chorionic gonadotropin were tested in the CSF of brain cancer patients. This evidence concerns the gene MUC16 and brain cancer.