Inflammatory cytokines such as TNF-α, array of interleukins, macrophage inflammatory protein (MIP)-1β and monocyte chemoattractant protein-1 (MCP-1) in blister fluid [169], IL-1β and IL-6 in cerebrospinal fluid [170], and neuropeptide SP [171] are suspected to be the primarysources of inflammation in CRPS [172]. This evidence concerns the gene TNF and complex regional pain syndrome.