BTG2 and neoplasm: In addition to negatively regulating cell cycle progression in response to DNA damage and other stresses [81], the tumor-suppressor function of BTG2 in the prostate epithelium was also demonstrated by the downregulation of BTG2 expression in non-tumorigenic prostate cells, which caused prostate cell transformation through induction of the epithelial-mesenchymal transition (EMT) phenotype [82].