CDK1 and pachyonychia congenita: Boll et al. recently demonstrated that miR-205, miR-203, and miR-130a are jointly downregulated in PC; reconstitution of miR-205 in androgen-dependent PC cells resemble the effect of androgen deprivation, including changes in cell morphology and impeded growth by suppressing several AR coactivators, including CDK1, PSAP, PSMC3IP, and PARK7 [132].