Advances in detection techniques, such as magnetic resonance imaging [2,3] and prostate-specific antigen (PSA) screening [4,5] have led to PC diagnoses at earlier stages, at which patients are typically treated with surgery, radiation, and in some cases, active surveillance only, and a majority of them are successfully cured of the disease [6,7,8]. This evidence concerns the gene KLK3 and pachyonychia congenita.