Since the identification of the association between the CDKN2B/CDKN2B-AS1 locus and POAG in the Australian cohort, several GWASs have replicated this association in the US Caucasian [42], Japanese [43,44,45], Asian, African, and European populations [48], providing strong evidence for the association of this locus with POAG. Here, CDKN2B is linked to open-angle glaucoma.