SIX1 and open-angle glaucoma: However, except for the glutathione-S transferase (GST) polymorphism, none of these loci have been either found to be associated with POAG (e.g., CAV1/CAV2, CDC7/TGFBR3, FNDC3) or the association has not been reported yet (e.g., ATOH7, CDKN2B(-AS1), SIX1/SIX6, TMCO1) in the Middle Eastern population.