CDC7 and open-angle glaucoma: The study confirmed and provided strong evidence of an association at the CDKN2B-AS1 locus (rs2157719, OR = 0.71, p = 2.81 × 10−33), and also identified SNP rs1192415 in the CDC7-TGFBR3 gene (1p22) showing significant association with POAG (OR = 1.13, p = 1.60 × 10−8) in the Asian, African and European populations, as well as SNP rs4894796 in FNDC3B (3q25.31) showing a significant association in Asians only (OR = 0.89, p = 7.93 × 10−8).