The causative genes that are capable of causing POAG with minimal influence from other gene(s) or the environment and that have been consistently implicated so far include myocilin (MYOC), optineurin (OPTN), WD repeat domain 36 (WDR36), ankyrin repeat and SOCS-box containing 10 (ASB10), Cytochrome P450 family 1, subtype B, polypeptide 1 (CYP1B1), and neurotrophin 4 (NTF4) as reviewed elsewhere [31,32]. This evidence concerns the gene OPTN and open-angle glaucoma.