Silencing cyclin D1 leds to a delay in growth of PCa cells: PC3- and 22Rv1-Cyclin D1-shRNA transduced cells respectively demonstrated a 5-fold decrease at 10-days and a 2-fold decrease at 12 days in proliferation compared to control-shRNA transduced cells (Figures 2B and 3B). The gene discussed is CCND1; the disease is posterior cortical atrophy.