Signaling pathways activated by intrinsic or extrinsic stimuli responsible for eliciting EMT/MET converge on transcription factors (TFs) ultimately regulating the phenotypic changes, like Snail family zinc finger (SNAI)1 and SNAI2 that impart mesenchymal traits to tumor cells including increased motility and invasiveness, and are responsible for transcriptional repression of E-cadherin [20, 21]. This evidence concerns the gene CDH1 and neoplasm.