Although it was not feasible to evaluate systematically and quantitatively the cancer invasive edge in the ccRCC samples available for this study, qualitative IHC analysis of single-antigen immunolabelling showed Ki-67 (Figure 3G) to be mainly expressed in the tumor core where MICAL2 (Figure 3H) was not or scarcely expressed, and vice versa (Figure 3I, 3J). Here, MICAL2 is linked to nonpapillary renal cell carcinoma.