All through the text, cell lines are designated as follows: parental, untreated cancer cell lines as ‘WT’; cells transfected with control plasmid (either TRCN0000192634 or empty pLKO.1-Neo-CMV-tGFP) as ‘CTRL’ cells; 786-O MIC2-KD clones as KD2 (obtained from tranfection with a single plasmid, TRCN0000046581) and KD14 (obtained from simultaneus transfection with three plasmids plasmids TRCN0000046579, TRCN0000046580 e TRCN0000046581); MERO-14 MIC2-KD cells as KDM1; MDA-MB-231 MIC2-KD cells as KDM4. The gene discussed is KDM1A; the disease is cancer.