As shown in Figure 3H, hTERT overexpression increased the binding of hTERT and c-Myc to the Hpa promoter; while depletion of hTERT resulted in reduced binding to the promoter region, indicating that hTERT could promote the formation of the transcriptional complex and recruit c-Myc to the Hpa promoter and, consequently, increase the expression of Hpa in GC cells. The gene discussed is HPSE; the disease is gastric cancer.