At week10, we observed a further progression of cardiac dysfunction, EF and IVSd significantly decreased and BNP level significantly increased, associated with increased plasma NE levels, fibrogenic factor expression, increased inflammatory cytokines production, out-of-balanced RAAS axis, and development of left atrioventricular and renal fibrosis, and all of these changes were reversed by RDN. This evidence concerns the gene NPPB and renal fibrosis.