Interestingly, the distribution of BRCA1, BRCA2 and ATM rare germline truncations with their somatic mutations across cancer types varies with the high frequency of ATM in prostate, lung and stomach cancers, and BRCA1 and BRCA2 germline events in ovarian and breast cancers (Fig. 5a and Supplementary Data 17). This evidence concerns the gene BRCA1 and cancer.