The average age at diagnosis of BRCA1 and BRCA2 germline truncation carriers versus non-carriers was non-significantly younger for endometrial (52.7 versus 63.1), stomach (59.7 versus 66.1) and lung (63.0 versus 66.1) cancers, providing support that these variants may contribute to younger onsets of these cancer types, though additional data is required for confirmation and to reach statistical significance. This evidence concerns the gene BRCA2 and cancer.