The joint analysis of all 12 cancer types including cancer type as a covariate identified BRCA1, BRCA2 and PMS2 as having strong correlations with a younger age of onset (P=5.20e-07, 2.04e-04 and 0.049, respectively; MuSiC GLM analysis, Fig. 5c and Supplementary Data 19). This evidence concerns the gene PMS2 and cancer.