In the same study, treatment of MM tumor bearing SCID mice with IL-1R antagonist (Anakinra) resulted in significantly decreased levels of IL-8 and VEGF in peritoneal lavage fluid (PLF), suggesting that IL-1 cytokines may play a significant role in regulating other pro-tumorigenic cytokines and, therefore, tumorigenesis. This evidence concerns the gene IL1B and neoplasm.