To understand the process of inflammasome regulation by chemotherapeutics in MM cells, Hmeso cells were treated with Dox alone or in combination with various inhibitors known to regulate inflammasomes in various systems (CA-074Me/cathepsin B inhibitor, cytochalasin D/actin polymerization inhibitor, KCl/blocks K+ efflux, KN-62/ATP receptor antagonist, NAC/antioxidant). Here, CTSB is linked to Miyoshi myopathy.