To show that activated caspase-1 contributes to drug-induced cell death (pyroptosis), we pretreated MM cells with a specific caspase-1 inhibitor (40 μM Caspase-1 inhibitor VI (zYVADfmk), EMD Biosciences, Billerica, CA) for 1 h and subsequently with chemotherapeutic drugs, Dox (0–100 μM) or cisplatin (0–200 μM) for 24 h (Hmeso) and 72 h (H2373). The gene discussed is CASP1; the disease is Miyoshi myopathy.