DSG2 and neoplasm: This infectivity enhancement has become an area of research focus as Ad3 binding of the Desmoglein 2 (DSG2) receptor, a primary receptor for the Ad3 serotype, improves the tumor microenvironment for drug delivery as the interaction results in a signaling cascade that releases the tight epithelial adhesion that normally precludes white blood cell and therapeutic agent tumor penetration [14, 15].