Overall KCa3.1 immunostaining was increased in the epithelium of patients with asthma (P = 0.007; Fig 1D, data in S2 Table), driven largely by an increase in the severe group (P = 0.002 for severe asthma compared to healthy controls; P = 0.008 compared to mild asthma; Fig 1E, data in S3 Table). The gene discussed is KCNN4; the disease is asthma.