AKT1 and neoplasm: We supposed that the tumor-selective delivery of antibodies by oncolytic NDV limited the virus spreading into circulation system or normal organs, which might facilitate to diminish the side effects of antibody drug our previous study, it is proved that cHAb18 antibody directs against CD147 to inhibit matrix metalloproteinase-2/9 production and rearrange actin cytoskeleton via suppressing integrin-FAk-PI3K/Akt-girdin signaling pathway, thus suppressing cell invasion and motility [25].