Notably, it has been shown in wild-type but not Nrf2 KO mice that DMF significantly increases axon/myelin preservation with reduction in astrocyte activation in a model of experimental autoimmune encephalomyelitis [8], reduces the size of myocardial infarction in a coronary artery ligation (myocardial I/R) model [47], and improves neurological performance in the model of intracerebral hemorrhage [48]. The gene discussed is NFE2L2; the disease is myocardial infarction.