Furthermore, the DGCR8 rs1640299, DICER1 rs3742330 and rs13078, RAN rs14035, and XPO5 rs11077 as well as rs784567 of TARBP2 genes single nucleotide polymorphisms have demonstrated an association with tumor progression depending on the lymph node metastases. The gene discussed is DGCR8; the disease is neoplasm.