CCL2 and infection: In one model, which employed the rather resistant mouse strain SJL/J (similar to CBA/J) infected with the C. neoformans strain D52, the T helper 1 response was preceded by accumulation of neutrophils in the lung as early as 3 hours after infection together with increased macrophage inflammatory protein-1α (MIP-1α), monocyte chemotactic protein 1 (MCP 1/CCL2), and keratinocyte chemoattractant (KC), which are neutrophil and macrophage chemoattractants.