IL-33 is a potent inducer of type 2 cytokines including IL-5 and IL-13 by directly activating ST2 on innate immune cells and Th2 cells, and plays an important role in parasite infection, allergy and asthma (Schmitz et al., 2005, Komai-Koma et al., 2012, Saglani et al., 2013). Here, IL33 is linked to allergic disease.