The regulation of H3K9 and H3K27 methylation by G9a is not cell line- or cancer type-specific because knockdown of G9a in human A549 lung cancer cells also showed similar results (Supplementary Fig. S5A) and treatment of UNC0638 attenuated H3K27 methylation in A549 and MDA-MB-231 cells (Supplementary Fig. S5B). The gene discussed is EHMT2; the disease is lung cancer.