Even though MDD is a strong predictor of the amount of mtDNA [6], and even though the genetic correlation between amount of mtDNA and MDD computed from genome-wide SNPs [8, 17] was 46.7% (SE = 14.3%, p value = 3.53 × 10−4), SNPs at TFAM and CDK6 were not associated with MDD (p value = 0.70 for rs11006126, p value = 0.53 for rs445, from a linear mixed model). Here, TFAM is linked to major depressive disorder.