The increase of NSun2 levels observed in a variety of human cancers, including those originating in the colon, esophagus, stomach, liver, oral cavity, pancreas, uterus, cervix, prostate, kidney, bladder, thyroid, breast, and skin [25, 38], may be part of a program of senescence repression involving reduced levels of p27. Here, NSUN2 is linked to cancer.