Further, when we interrogated mRNA and miRNA profiles in patient data sets, we observed a trend towards (P=0.06 and P=0.17) a positive correlation between Six1 and miR-27a expression in the normal-like and ERBB2 subtypes of breast cancer, respectively, suggesting that in a context-specific manner, Six1 likely regulates miR-27a in human cancers (Supplementary Fig. 15b)38. This evidence concerns the gene SIX1 and cancer.