TGFB1 and hepatocellular carcinoma: This revealed that context-specific TGF-β-dependent genes are enriched for those with cell-type-specific epigenetic patterns, characterized by higher levels of gene-proximal open chromatin marks (H3K4me3, H3K27ac, and Pol II) (Figures 3B and 3C) and lower levels of repressive chromatin marks in the corresponding BTIC type (Figure S3E; HCC-unique genes depleted from H3K27me3; MDA-unique genes depleted from DNA methylation).