To test if this also occurs in BTICs, we systematically categorized SMAD3 binding events into three classes: (1) uniquely present in MDA-MB-231 (Figure 2D, red peak), (2) uniquely present in HCC-1954 (Figure 2D, blue peak), and (3) present in identical position in both cell types (Figure 2D, gray peaks). The gene discussed is SMAD3; the disease is hepatocellular carcinoma.