The over expression of insulin-like growth factor 1 receptor (Igf1R) in the development of tumors stimulates cell growth, survival and proliferation and regulates the initiation of cancer cell metastasis; the level of Igf1R is negatively associated with the level of miR-122 expression, implying that the overexpression of miR-122 can inhibit tumor cell growth and proliferation by suppressing Igf1R expression34. The gene discussed is IGF1R; the disease is neoplasm.