To investigate the effects of α-MSH on corneal dysfunctions in dry eye rats, the α-MSH at the doses of 10−5, 10−4, and 10−3 mg/ml were topically applied to the corneas of the scopolamine-induced dry eye rats on daily basis, clinical evaluations, including Schirmer’s test, tear breakup time (BUT), and corneal fluorescein staining were conducted every week. Here, STAMBP is linked to dry eye syndrome.