To explore the signaling pathways mediating α-MSH’s protective effects on the corneas of dry eye rats, H89 and PD98059, the two widely used pharmacological blockers that block PKA30 and Erk24 pathways, respectively, were applied with 10−4 mg/ml α-MSH everyday, then the clinical evaluations were performed on Day 28. Here, STAMBP is linked to Keratoconjunctivitis sicca.