CREB1 and Keratoconjunctivitis sicca: Therefore, a dramatic induction in p-CREB by α-MSH in the dry eye corneas and conjunctivas translated into a 2-fold enhancement in the ratio of p-CREB over total CREB relative to saline controls (Fig. 7A,C, D+α-MSH vs NaCl+NaCl, p < 0.01).