The tear secretion in 10−5 mg/ml α-MSH-treated dry eye group was similar to that in the saline-treated dry eye group except a significant elevation on Day 28 (Fig. 1A, p < 0.05, D+10−5 α-MSH vs D+NaCl). The gene discussed is STAMBP; the disease is Keratoconjunctivitis sicca.