TGFB1 and malignant mesothelioma: Moreover, Kim et al. analyzed ROS-induced EMT in human malignant mesothelioma (HMM) cells, and based on their findings, they suggested that oxidative stress induced by H2O2 may play a critical role in HMM carcinogenesis, which would involve TGF-β, hypoxia inducible factor–1α, and some genes related to the capacity of cells to preserve their undifferentiated phenotype (stemness genes) (Kim et al. 2013; Potten and Loeffler 1990).