Moreover, mutations in Rab proteins and their regulating factors cause motor and sensory pathologies, such as Charcot-Marie-Tooth type 2B (CMT2B) disease, which is caused by mutations in Rab7 (9) and a familial form of amyotrophic lateral sclerosis (ALS), which is linked to mutations in the Rab5 regulator alsin (10). This evidence concerns the gene AGFG1 and amyotrophic lateral sclerosis.