IRS2 and breast carcinoma: These genes include: transcription factor Dp-1 (TFDP1), cullin 4A (CUL4A), and cell division cycle 16 (CDC16) identified in hepatocellular carcinoma (HCC) [7], breast cancer [8], and lung cancer [9]; and insulin receptor substrate 2 (IRS2) present in colorectal cancer [10].