TFE3 is involved in chromosomal translocations that result in various gene fusions (such as PRCC-TFE3, RCC17-TFE3, PSF-TFE3, NONO(p54nrb)-TFE3 and ASPL-TFE3) in papillary renal cell carcinomas. The gene discussed is ASPSCR1; the disease is papillary renal cell carcinoma.