In this dataset, both intrinsic subtype and ROR-P were found to be significantly associated with DRFS in univariate and multivariable analyses after adjustment for age, tumor size, nodal status, ER and PR status, HER2 status, histological grade, and tumor response (pCR vs. residual disease) (Additional file 1: Table S1 and S2). The gene discussed is ERBB2; the disease is neoplasm.