However, it is important to note that GW3965 also lowered body weight as well as hyperglycaemia and hypercholesterolaemia in these mice whilst improving glucose tolerance and insulin sensitivity [16], suggesting that the beneficial effects of LXR agonism in the heart are likely to be a result of less stress emanating from these systemic metabolic disturbances. This evidence concerns the gene INS and Hypercholesterolemia.