Here, using a short-term explant model to expand and study T cells from surgical specimens, we report a significant population of IL-17RB–expressing TH2 cells in nasal polyps with a gene expression profile akin to that of highly polarized TH2 cells.25, 26 Approximately 50% of IL-5+IL-13+ polyp-derived CD4+ T cells expressed IL-17RB, suggesting IL-17RB+ cells represent a subset of TH2 cells. The gene discussed is IL17RB; the disease is polyp.