Banck et al. [13] performed exome sequencing of 48 small intestinal NETs and identified 197 protein-altering somatic single nucleotide variations with a preponderance of cancer-related genes such as FGFR2, MEN1, HOOK3, EZH2, MLF1, CARD11, VHL, NONO, and SMAD1. However, most of these mutations were not recurrently identified. This evidence concerns the gene VHL and cancer.