Thus, several markers deserve to be explored such as the S-100B protein known to be a marker of traumatic cerebral lesion, neurodegenerative diseases and aggressive gliomas [17], specific isoprostanes (as 8,12-iso-iPF2α-VI) implicated in the oxidative/nitrate stress in neurodegenerative diseases [18] and homocystein which plasma concentration has been associated with poor memory performances in old individuals [19]. The gene discussed is S100B; the disease is neurodegenerative disease.