Our network analysis of gene expression profiles has identified concurrent elevated expression of E-cadherin and downregulation of TGFβ2 expression in ovarian cancer 3D spheroids and clinical samples (Figure 3), suggesting that ovarian cancer 3D cultures and clinical tumors are more epithelial-like than OSE 3D cultures and normal ovarian surface epithelia and inclusion cysts. Here, CDH1 is linked to ovarian carcinoma.