FBN1 and Marfan syndrome: At the latest update of the UMD-FBN1 mutations database (http://www.umd.be/FBN1/ on 28/08/14), 1847 different mutations and 1096 protein variants have been identified in FBN1 [www.umd.be/FBN1/] in patients with MFS and a spectrum of related fibrillinopathies [2].