Apart from DUSP5, the other two genes present in the 2.4Mbp introgressed region of FHH.1BN rats include Add3 and aminopeptidase P. Add3 is one of the first genes reported to co-segregate with the development of hypertension in a cross of Milan normotensive and Milan hypertensive rats [23]. The gene discussed is ADD3; the disease is hypertensive disorder.