MKI67 and neoplasm: So far, studies focused on PanNETs have revealed overexpression of miRNA-21, miRNA-642 and miRNA-193b to be associated with increased proliferative activity and metastasis in PanNETs.15,21 We demonstrate herein that increased expression of miRNA-196a is correlated with increased tumor grade (i.e. proliferative activity demonstrated by Ki-67 and mitotic indices), higher tumor stage, and other features of aggressive behavior such as lymphovascular invasion and lymph node metastasis in PanNETs.