RB1 and cancer: The viral protein E6 promotes the degradation of p53 and E7 inactivates pRb, usually followed by viral integration into the host genome.32,33 Recently, a genome-wide study using whole genome sequencing revealed HPV integration sites associates with recurrent focal genomic instability.34 This study showed a small fraction of HPV 16 directly integrated into the midst of a chromosomal translocation, juxtaposing between 11q13 and 8p11, implying that CNV in HPV+ cancers might exhibit unique patterns, connected to the viral integration process.