For example, examining the refined adenocarcinoma only, PR only, DMxDE network for adenocarcinoma displayed the known cancer-related genes [TP53, Akt, NQO1], but also myriad additional nodes [SMARCA4, ITGB1, CTNNB1, Hsp70, AR, others], to date of unknown significance. The gene discussed is CTNNB1; the disease is cancer.