In this study, we utilized the TgF344-AD transgenic rat model of Alzheimer’s disease (AD) that over-expresses “Swedish” mutant human amyloid precursor protein and Δ exon 9 mutant human presenilin-1, and progressively develops cognitive impairment and the full spectrum of AD-like pathological features [18]. This evidence concerns the gene PSEN1 and Alzheimer disease.