At the same time, only some BAP1 mutant families experience a high prevalence of MM, suggesting that in some families a low level of asbestos exposure may be a co-factor [28], while other families have higher prevalence of different tumor types, such as melanomas, etc. Indeed, we recently published that BAP1+/- mice were susceptible to develop MM when exposed to very low levels of asbestos, levels that rarely trigger MM in wild-type mice [29]. This evidence concerns the gene BAP1 and melanoma.