TNF and rheumatoid arthritis: For example, HLA-DRB3 and G0/G1 Switch 2 (G0S2) expression have been reported to predict response to anti-TNF therapy [32, 33], while Interferon, Alpha-Inducible Protein 27 (IFI27) and Troponin I type 2 (TNNI2) appear to be involved in RA onset or progression [34, 35].