Here we demonstrated that single low-dose Dox (4 mg/kg i.p.) or Tax (10 mg/kg i.p.) administered one day prior to ACT which used fewer numbers of CD8+ T-cells (i.e. Dox + 2 × 106 T cells or Tax + 2 × 106 T cells) could achieve the same tumor inhibition efficacy as that of 5 × 106 T cells group. Here, CD8A is linked to neoplasm.