Ever users were characterized by younger age, less males, higher proportions of eye disease, dyslipidemia, peripheral arterial disease and tobacco abuse, lower proportions of hypertension, nephropathy, stroke, ischemic heart disease, chronic obstructive pulmonary disease and alcohol-related diagnoses, higher proportions of use of rosiglitazone, statin and non-steroidal anti-inflammatory drugs excluding aspirin, but lower proportions of using other antidiabetic medications, angiotensin converting enzyme inhibitor/angiotensin receptor blocker and aspirin (Table 1). The gene discussed is ACE; the disease is Hypertension.