Emodin suppresses activation of JAK/STAT signaling in leukemia cells by inhibiting the kinase CK2, inhibits interleukin-6-induced JAK2/STAT3 signaling in myeloma cells, and suppresses STAT3 activation through upregulation of SHP-1 in hepatocellular carcinoma cells [14–16]. Here, STAT3 is linked to hepatocellular carcinoma.