TSC1 and neoplasm: This analysis revealed that pancreatic epithelial cells in p53-/-; Tsc1-/+ mice and tumor cells (and atypical acinar cells) in p53-/-; Tsc1-/- mice were generally devoid of p-AktSer473 and p-Erk1/2Thr202/Tyr204 (Fig. 3d, e); pancreatic acinar cells of p53-/-; Tsc1-/+ mice had detectable levels of p-mTORSer2448 and p-S6Ser235/236; however, the staining intensities in the tumor cells (and atypical acinar cells) of p53-/-; Tsc1-/- mice were more pronounced (Fig. 3f, g).